AMI-193
- Product Name
- AMI-193
- CAS No.
- 510-74-7
- Chemical Name
- AMI-193
- Synonyms
- R 5808;AMI-193;spiramide;Fluroxyspiramine;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]-DECANONE;8-[3-(4-FLUOROPHENOXY)PROPYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE;1-Phenyl-8-[3-(4-fluorophenoxy)propyl]-1,3,8-triazaspiro[4.5]decane-4-one;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-
- CBNumber
- CB2728009
- Molecular Formula
- C22H26FN3O2
- Formula Weight
- 383.46
- MOL File
- 510-74-7.mol
AMI-193 Property
- Melting point:
- 176 - 179°C
- storage temp.
- Store at RT
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- White solid.
- color
- Off-White to Pale Yellow
N-Bromosuccinimide Price
- Product number
- 0524
- Product name
- AMI-193
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $122
- Updated
- 2021/12/16
- Product number
- 0524
- Product name
- AMI-193
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 254616
- Product name
- AMI-193
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- A576605
- Product name
- AMI-193
- Packaging
- 50mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- CS-0020651
- Product name
- Spiramide
- Purity
- 98.81%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
AMI-193 Chemical Properties,Usage,Production
Uses
AMI-193 is a selective 5-HT2A and D2DR receptor antagonist. Endoplasmic reticulum (ER) stress inducer; Also, it is derived from 4-Fluorophenol (F595325), which is a fluorinated phenolic compound with various applications as an starting reagent for the synthesis of pharmaceutical goods.
Definition
ChEBI: An azaspiro compound that consists of 1,3,8-triazaspiro[4.5]decan-4-one having a phenyl group attached to N-1 and a 3-(4-fluorophenoxy)propyl attached to N-8. Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spipero e but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behaviour.
Biological Activity
Selective 5-HT antagonist, which binds to 5-HT 2 sites as potently as spiperone but has lower affinity for 5-HT 2C receptors. Also a high affinity D 2 receptor antagonist (K i = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.
References
[1]. czoty pw, howell ll. behavioral effects of ami-193, a 5-ht(2a)- and dopamine d(2)-receptor antagonist, in the squirrel monkey. pharmacol biochem behav, 2000, 67(2): 257-264.
[2]. ismaiel am, de los angeles j, teitler m, et al. antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-ht2- versus 5-ht1c-selective antagonist. j med chem, 1993, 36(17): 2519-2525.
[3]. luparini mr, garrone b, pazzagli m, et al. a cortical gaba-5ht interaction in the mechanism of action of the antidepressant trazodone. prog neuropsychopharmacol biol psychiatry, 2004, 28(7): 1117-1127.